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Vitamin C injections are generally well tolerated at medically appropriate doses, but high doses can lead to iron overload, kidney stones, and kidney damage

4) Berberine activates AMPK to reduce lipid peroxidation and ferroptosis, mitigating I/R-induced renal fibrosis in mice (201)

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Accelerating the course of liver fibrosis Hepatic stellate cells (HSCs) are liver-specific mesenchymal cells that retain features of resident fibroblasts